In concordance, it was found that the polarity determinants CDC42, PAR6B and aPKCι, and the structural proteins ezrin and phospho-ezrin, were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in MVID patients, which suggests an inversion of cell polarity (Michaux et al., 2016). The gene discussed is CDC42; the disease is microvillus inclusion disease.