MYO5B and microvillus inclusion disease: In summary, MYO5B KD in LS174-W4 and in Caco-2/Caco-2BBE cells recapitulates the polarity defects that are observed in the enterocytes of MVID patients, albeit to varying degrees (Dhekne et al., 2014; Knowles et al., 2014; Kravtsov and Ameen, 2013; Müller et al., 2008; Thoeni et al., 2013; Vogel et al., 2015).