In addition, microvilli have been found to be mislocalized to the basolateral membrane, particularly in patients with MVID caused by STX3 mutations (Wiegerinck et al., 2014), and in two MVID mouse models, the enterocyte-specific Rab8a; Rab11a double, and the Rab11a single, knockout mice (Feng et al., 2017). This evidence concerns the gene RAB8A and microvillus inclusion disease.