Although it is not yet clear whether basolateral membranes are affected in MVID, the mislocalization of basolateral proteins, such as transferrin receptor and α2-integrin to the cytoplasm has been reported in some MVID patients and mouse models (Schneeberger et al., 2015; Thoeni et al., 2013). The gene discussed is TFRC; the disease is microvillus inclusion disease.