CFH and Autoimmunity: Systemic CFH deficits are conducive to excessive and pathogenic complement activation associated with increased complement activity in healthy host cells, autoimmunity, host tissue damage, and a sustained or chronic inflammatory response (Alexander and Quigg, 2007; Griffiths et al., 2009; Song et al., 2009; Deangelis et al., 2011; Li et al., 2012).