CFH and Alzheimer disease: Furthermore, we determined the effect of miR-146a on CFH and found that enhancive miR-146a could downregulate the expression of CFH, similar to the findings in the AD field (Lukiw et al., 2008, 2012a; Hill et al., 2009; Pogue et al., 2009; Li et al., 2011; Lukiw, 2012).