Further supporting the concept that LSD1 inhibitors induce phenotypic consequences in hematopoiesis through the SNAG domain displacement mechanism, it is interesting to note that adult mice treated with inhibitors of LSD1 (Harris et al., 2012), or in whom LSD1 is depleted (Sprüssel et al., 2012) or deleted (Kerenyi et al., 2013), exhibit anemia, thrombocytopenia, and neutropenia but enhanced monocytopoiesis. The gene discussed is KDM1A; the disease is anemia (phenotype).