These initial analyses demonstrate that the early and extensive transcriptional consequences of LSD1 inhibition by OG86 in THP1 AML cells are not immediately preceded by the selective accumulation of H3K4Me1 and H3K4Me2 (the targets of LSD1’s histone demethylase activity) at LSD1-bound active enhancers and upregulated promoters. Here, KDM1A is linked to acute myeloid leukemia.