RCOR1 and acute myeloid leukemia: Together, these data demonstrate that, in THP1 AML cells, both irreversible and reversible pharmacologic inhibitors of LSD1 displace the LSD1/RCOR1 complex from its physical interaction with GFI1 and that loss of histone deacetylase activity at GFI1 binding sites is, at least in part, responsible for differentiation.