KDM1A and acute myeloid leukemia: While accumulation of H3K4Me1/2 marks has been reported in AML cells following LSD1 inhibition (Schenk et al., 2012, McGrath et al., 2016), it is not clear that this is a direct and localized consequence of the blockade of the catalytic activity of LSD1 rather than an indirect consequence of enhancer activation at sites distant from LSD1 binding.