GFI1 and acute myeloid leukemia: In keeping with the physical separation of LSD1 and RCOR1 from GFI1 induced by OG86 in immunoprecipitation experiments, we observed a loss of LSD1 and RCOR1 ChIP-seq signal in OG86-treated THP1 AML cells, indicating that drug treatment compromized the interaction of co-localized LSD1/RCOR1 with chromatin (Figures 3A, 3E, S3F, and S3G).