For example, GFI1 or GFI1B are oncogenic drivers in medulloblastoma (Northcott et al., 2014), GFI1 represses TP53 in T-acute lymphoblastic leukemia to prevent apoptosis (Khandanpour et al., 2013), and SNAIL family transcription factors are master regulators of the epithelial-to-mesenchymal transition, an essential aspect of cancer cell migration and metastasis (Ferrari-Amorotti et al., 2013, Lamouille et al., 2014). The gene discussed is SNAI1; the disease is acute lymphoblastic leukemia.