MAPT and frontotemporal dementia: Mutations in the MAPT gene are causal for some familial forms of FTD (Ghetti et al., 2015), and the formation of intracellular, hyperphoshorylated aggregates of tau (neurofibrillary tangles [NFTs]) is a common pathological feature in AD, FTD, and other dementias (Grundke-Iqbal et al., 1986, Kosik et al., 1986).