NKp46-deficient mice (Ncr1gfp/gfp) have been widely used to demonstrate the importance of NKp46 in the control of microbial infection (Gazit et al., 2006) and tumor development by NK cells (Glasner et al., 2012) as well as in contributing to type 1 diabetes (Gur et al., 2010). This evidence concerns the gene NCR1 and neoplasm.