The ATA currently recommends prophylactic thyroidectomy for all RET mutation carriers, stating, “...the question is not whether prophylactic thyroidectomy should be performed in patients with hereditary MTC, but at what age?” Whereas prophylactic thyroidectomy in early childhood (<5 years) is recommended unequivocally for children carrying mutations categorized as high and highest risk, the recommendations are less didactic for moderate-risk mutations, such as p.Val804Met. This evidence concerns the gene RET and medullary thyroid gland carcinoma.