During skeletal muscle contraction, the activation of the AMP-activated protein kinase (AMPK) in response to the increased ATP demand (30) favors the translocation of type 4 glucose transporter (GLUT 4) to the plasma membrane increasing glucose uptake (31, , –34), which is associated with decreased glycemia and the consequent hypoglycemia (35). This evidence concerns the gene SLC2A4 and Hypoglycemia.