REN and hypertensive disorder: The time course of the 2K1C model is divided into phases after clipping of the renal artery: i) 4 weeks: blood pressure increases, which is associated with increases in plasma renin activity and circulating AngII concentration; ii) 5–8 weeks: hypertension associated with increasing RAS components in tissue, despite reduced plasma renin activity and circulating AngII; iii) 9 weeks and later: hypertension is maintained by increased activity of tissue RAS at the level of plasma volume and in a sympathetic manner.