If serum klotho level was high (≥14 pg/mL), the odds ratios (ORs) of interstitial fibrosis (OR = 0.019, P = 0.003) and segmental sclerosis (OR = 0.190, P = 0.022) were decreased after adjustment for age, gender, BMI, DM, HTN, eGFR, and log UPCR (Table 3). This evidence concerns the gene KL and diabetes mellitus.