Conversely, the principal ingredients (core mix) of a nutraceutical product used to treat hair loss potently promotes autophagy in organ-cultured human scalp HFs (Fig 6A–6E) and promotes anagen (Fig 7A and S3 Fig), but fails to do so in ATG5-silenced HFs (Fig 7B). The gene discussed is ATG5; the disease is Hand-foot syndrome.