Patients with lower SHBG (<30 nmol/L: adjusted HR = 4.98, 95% CI 2.45–10.11, p < 0.001; <20 nmol/L; adjusted HR = 4.75, 95% CI 2.44–9.25, p < 0.001) had increased rates of NAFLD (Fig 3B, S16 and S17 Tables). The gene discussed is SHBG; the disease is metabolic dysfunction-associated steatotic liver disease.