PDK4 and malignant colon neoplasm: In the supplementary (Additional file 1) we show: (1) CPNE4, EPHA7, and LOC286297, which are among the top 20 genes of all three algorithms that rank genes, are shown to be involved in colon cancer, (2) many of the top 20 genes in common between two of the gene ranking algorithms, such as the GAGE genes, RYR3, PDK4, and MYH11, are suggested to be involved in colon cancer, and (3) among the common top 20 enriched pathways, the plasminogen activating cascade, blood coagulation, and the beta1 adrenergic receptor signaling pathway are suggested to be involved in colon cancer.