Studying the top 20 genes and pathways in the supplementary (Additional file 1) we see that ORM1, ORM2, LTF, CAMP, LCN2, MMP9, CYP4F3, WT1, and CRISP3 are among the top 20 genes of all gene ranking algorithms, and are shown or suggested to be involved in AML. The gene discussed is CYP4F3; the disease is acute myeloid leukemia.