Two members of the vanilloid subfamily, TRPV5 and TRPV6, are permeable to calcium with high selectivity (PCa/PNa > 100), while others are weakly selective (PCa/PNa ≤ 12) or not calcium selective at all (TRPM4 and TRPM5) [7–9]. The gene discussed is TRPV5; the disease is posterior cortical atrophy.