However, the strong correlation between Ki ratio (i.e., 3P-KMA/Patlak) and kb (and hence, between Ki underestimation by Patlak’s analysis and kb; Fig. 5) suggests that 3P-KMA may be more appropriate than Patlak’s analysis to accurately assess Ki in various 18F-FDG-positive cancer lesions, possibly showing greater trapping reversibility than lung cancer lesions [9–11]. This evidence concerns the gene PSME3 and lung carcinoma.