KLK3 and posterior cortical atrophy: Although Ploussard et al. [5] and Joniau et al. [6] stratified the patients with D’Amico high-risk PCa including the cT3 and cT4 stages who were treated with RP into 3 prognostic categories using clinical T stage (< cT3 vs cT3–4), Gleason score (GS, < 7 vs 8–10) and prostate specific antigen (PSA, ≤ 20 vs > 20 ng/ml), these studies involved patients treated with adjuvant treatments after RP.