In order to validate the underlying roles and mechanisms of TP53TG1 in enhancing the sensitivity of NSCLC cells to cisplatin, A549/DDP cells infected with lenti-control or lenti-TP53TG1 were subcutaneously injected into the nude mice to generate xenograft, followed by treatment with cisplatin or PBS. The gene discussed is TP53TG1; the disease is non-small cell lung carcinoma.