To further explore whether the enhancement effect of TP53TG1 on cisplatin sensitivity of NSCLC was mediated by miR-18a, A549/DDP cells were transfected with pcDNA-TP53TG1 alone or together with miR-18a mimics, and A549 cells were transfected with si-TP53TG1#1 alone or together with anti-miR-18a. The gene discussed is TP53TG1; the disease is non-small cell lung carcinoma.