ERBB2 and cancer: EGCG increases the expression of tumor suppresser genes, e.g., p53 [27], and suppresses receptors or signaling proteins involved in the proliferation pathways in various cancer cells, including the epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), insulin like growth factor receptor (IGF), and mitogen-activated protein kinase (MAPK) [28, 29].