In case of pancreatic cancer, combination of the nomogram with CA19-9 and CEA resulted in slightly increased AUC values (AUCnomogram + CA19-9 level = 0.81, p = 0.87; AUCnomogram + CEA level = 0.83, p = 0.07). Here, CEACAM5 is linked to familial pancreatic carcinoma.