STAT3 and breast cancer: Positive correlations were observed with cell cycle regulatory proteins such as GATA3 (p < 0.0001), and STAT3 (p < 0.0001), markers also known to be highly expressed in ER+ BC associated with favourable outcome.34, 35 Expression of histone modifiers that influence hormone-responsive gene expression in BC36 were also positively associated with MED7 expression: viz., histone methylation modifiers at lysine (H3K4Me2: p = 0.041; H4K12ac: p = 0.004) and arginine residues (H4R3Me2; p = 0.048) (Table 3).