It is noteworthy that 2 of these LCA cases (RP-1613 and RP-2140, Table 1), had diverse symptoms of hypopituitarism, and both bore de novo nonsense OTX2 variants: p.(Trp85*) and p.(Gln187*), respectively (Fig. 2). This evidence concerns the gene OTX2 and Leber congenital amaurosis.