Further, there was still a significant positive trend between HOMA-IR and NIHSS score (P=0.003), using ordered logistic regression after multivariate adjustment for possible confounders: age, sex, BMI, infarct volume, time from onset to blood collection, stroke syndrome, stroke etiology, pre-stroke treatment, physical activity, vascular risk factors, and serum levels of Hs-CRP, FBG, HDL, LDL, and triglycerides. The gene discussed is CRP; the disease is Stroke.