As members of the Dock-C family, Dock7 was reported to promote the metastasis of tumors including GBM tumor cells, Esophageal Squamous Cell Carcinoma (ESCC) and glioblastoma [25–27]; Dock6 has been reported to be involved in polarized axon growth; and Dock8 can increase the motility of immune cells [28, 29]; however, the expression profile and the role of Dock6 and Dock8 in tumors remains unknown. Here, DOCK8 is linked to esophageal squamous cell carcinoma.