Wound healing experiments showed that Dock6 over-expression up-regulated the migration ability of SGC-7901NM cells, while NSC23766 and ML141 could reverse Dock6-mediated cell migration (Fig. 3c), suggesting that Dock6 contributed to GC metastasis by increasing the activation of Rac1 and Cdc42. The gene discussed is RAC1; the disease is gastric cancer.