Together our similar findings in pancreatic islets and pituitary gland i) suggest similar mechanisms in counter-acting high classical HLA class I expression, ii) suggest the prevention of autoimmunity by downregulating effector functions of potential auto-reactive lymphocytes and iii) further strengthens the hypothesis that HLA-G expression of endocrine cells might be correlated to their secretory activity [38]. Here, HLA-G is linked to Autoimmunity.