Especially the highly tissue-restrictive physiological expression and its immune-suppressive functions makes HLA-G an interesting molecule in cancer research: as tool for the development of universal (HLA class I negative) T cells for adoptive T cell transfer [55], blockade of HLA-G expression and function on tumor cells may be a potential target for antitumor therapy [40] or as diagnostic and prognostic biomarker [56]. This evidence concerns the gene HLA-G and neoplasm.