ST3GAL5 and brain neoplasm: PLEKHA5 facilitates cell migration and invasion and is linked to brain tumor metastasis via the PI3K-AKT pathway [24, 25], whereas ST3GAL5 encodes a sialyltransferase that catalyzes the formation of ganglioside GM3, a suppressor of EGFR/PI3K-AKT signaling and cell proliferation, and a inducer of apoptosis [26, 27].