SCAP and cancer: A total of 43 genes reside within 10 kb of these regions (Additional file 1: Table S10, column B), including those involved in cancer pathways (e.g. MMP2), angiogenesis (e.g. VEGFA), hypoxia response (e.g. SCAP), and neural development (e.g. KCNQ2), with downregulation of these loci being the dominant transcriptional effect (Additional file 1: Table S3).