When it comes to glioblastoma (GBM), a study carried out by Cui et al. demonstrates that reduced mRNA m6A level is critical for maintaining glioblastoma stem-like cell (GSC) growth, self-renewal, and tumor development as downregulation of METTL3 or METTL14 expression reduces mRNA m6A levels of theirs target gene A disintegrin and metallopeptidase domain 19 (ADAM19) and promotes ADAM19 expression. This evidence concerns the gene METTL14 and glioblastoma.