For example, FTO, an m6A demethylase, is highly expressed in AML with t(11q23)/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD, and/or NPM1 mutations and functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and inhibits all-trans-retinoic acid (ATRA)-mediated leukemia cell differentiation. Here, NPM1 is linked to acute myeloid leukemia.