LSL-KrasG12D/+; Pdx1-Cre (KC) and LSL-KrasG12D/+; Trp53fl/+; Pdx1-Cre (KPC) mice, in which Pdx1 induces the expression of mutant Kras alone or together with mutant Trp53 in murine pancreatic epithelium, fully recapitulate the pathogenesis of human PDAC and are generally regarded as two of the best genetically engineered mouse models (GEMMs) for human PDAC. This evidence concerns the gene TP53 and keratoconus.