Since in our previous report, we had observed an association between Gln27Glu polymorphism of ADRB2 gene, obesity, and other related disorders in Saudi population [9] our interest was to explore if any association existed between ADRB1 (rs1801253) and ADRB3 (rs4994) and these abnormalities. This evidence concerns the gene ADRB1 and obesity due to melanocortin 4 receptor deficiency.