In fact, our findings for Arg389 Gly polymorphism in ADRB1 amongst Saudi population are in line with earlier published reports [7, 21, 61, 62] and suggest that ADRB1 Arg389Gly polymorphisms do not contribute to obesity and related disorders in the Saudi population. Here, ADRB1 is linked to obesity due to melanocortin 4 receptor deficiency.