Masuo and Lambert [10] have reviewed various studies about the relationship of polymorphism in either Gly49-Gly389 or Ser49Gly- Arg389Gly in ADRB1 with obesity or obesity related disorders and have reported contradicting findings among different populations which means that the relationship of ADRB1 polymorphism to obesity could vary between different populations. This evidence concerns the gene ADRB1 and obesity due to melanocortin 4 receptor deficiency.