Similarly, Rottoli et al. [55] found that IPF patients had significantly higher concentrations of oxidised BALF proteins than controls through a proteomic approach, which revealed that protein carbonylation involved specific carbonylation-sensitive proteins, and that in IPF a greater number of proteic targets of oxidation were present, including albumin, transferrin, α1-antitrypsin, complement C3, SOD, ceruloplasmin, pulmonary surfactant-associated protein A, and many others. This evidence concerns the gene C3 and idiopathic interstitial pneumonia.