PCSK1 and systemic inflammatory response syndrome: In a model of TNF-induced SIRS, pretreatment with necrostatin-1 or Nec-1 s strongly inhibited lethality [107], and this finding was supported by studies showing that RIPK1 kinase-inactive mice are also resistant to the lethality of TNF-induced SIRS and to the lethality of septic shock induced by a combination of TNF and Z-VAD-FMK [106, 108, 109].