AKT1 and gastric cancer: In gastric cancer, Reg IV enhances peritoneal metastasis and inhibits apoptosis through upregulation of the level of several anti-apoptosis factors: Bcl-2, Bcl-XL, survivin, phosphorylated Akt, and phosphorylated EGFR; and deregulation of nitric oxide and 5-FU induced apoptosis [17, 18].