PTGS2 and cancer: Compared to the classic COX inhibition strategy in cancer treatment, our novel strategy will result in dual inhibitory effects on cancer, which not only limits deleterious PGE2 formation from arachidonic acid (the common objective of COX-2 inhibitor), but also promotes formation of 8-HOA via capitalizing on high COX-2 expression in cancer as well as the abundance of ω-6 s in the daily diet.