EDN1 and Myocardial fibrosis: The present study indicated that the effect of ET-1 on changing the structure of the left ventricle may be related to the following factors: ET-1 can stimulate myocardial fibroblast Type I and Type III collagen proliferation and synthesis and promote myocardial collagen network reconstruction, which plays an important role in myocardial fibrosis and remodeling.