It was shown that LATS1/2 are functional targets of CRL4DCAF1 and that in tumors with mutated NF2, such as mesothelioma, activated CRL4 induces LATS1/2 ubiquitination to promote their degradation and YAP/TAZ activation, thus stimulating oncogenesis [66] (Figure 2, shown in purple). The gene discussed is WWTR1; the disease is mesothelioma.