PTEN and mesothelioma: Considering the reports of mTORC2 activation in mesothelioma cells due to the loss of PTEN, which is an mTORC2 negative regulator, or the increased phosphorylation of mTORC2 substrate AKT [79,99], PI3K/mTOR dual inhibitors are predicted to be more effective in suppressing mesothelioma growth than rapalogs.