UCP2 and pancreatic adenocarcinoma: The potentiation effect of genipin on anticancer agents in vitro via UCP2 inhibition and associated ROS generation has now been established for various drugs, including for the cytotoxic effect of cisplatin in colon cancer cells [36], breast cancer cells (MCF-7 and T47D) exposed to several chemotherapeutic agents [196], and various pancreatic adenocarcinoma cell lines (PaCa44, PaCa3, Panc1, CFPAC1, T3M4, and MiaPaCa2) exposed to gemcitabine [197].