TP53 and central nervous system cancer: For example, Chang et al. [51] demonstrated an increase in p53, c-Myc, and B cell lymphoma gene 2 (BCL2) associated X (Bax) coupled with a decreased protein levels of B cell lymphoma gene 2 (Bcl-2) associated with the cytotoxic effect of penta-acetylated geniposide in C6 glioma cells.