RB1 and central nervous system cancer: The study by Chang et al. [51] on C6 glioma cells apoptosis and cells cycle arrest at the G0/G1 (G1–S transition) phase by this compound (0.3 mM) similarly revealed p53 and c-Myc induction that also involved Bcl-2 family proteins, a decrease in the protein expression of cyclin D1, increased levels of cyclin-dependent kinase (cdk) inhibitor p21 protein, suppressed formation of cyclin D1/cdk 4 complex, inhibition of the phosphorylation of retinoblastoma (Rb), and dissociation of the Rb/E2F complex.