While SYK can be targeted with fostamatinib [85,91,92], the small-molecule inhibitor dasatinib, which was initially utilized as an inhibitor of the oncogenic BCR-ABL fusion protein in chronic myelogenous leukemia, was shown to inhibit also LYN and BTK in CLL [93,94,95]. Here, BTK is linked to B-cell chronic lymphocytic leukemia.