Aberrant induction of MALT1 protease activity is a major consequence of constitutive CBM signaling and has been reported to be essential for the survival of several lymphoid malignancies, such as ABC DLBCL, MCL, and CLL, making MALT1 an attractive therapeutic target in lymphoma treatment [150,151,152,153]. The gene discussed is MALT1; the disease is B-cell chronic lymphocytic leukemia.