At advanced stages, however, these MALT lymphomas are associated with distinctive chromosomal translocations, which either lead to the overexpression of BCL10 and MALT1 [143,144,145] or result in the generation of a constitutively active fusion protein comprising the N-terminal part of cellular inhibitor of apoptosis protein 2 (cIAP2, also known as API2) and the C-terminus of MALT1 [24,146,147]. This evidence concerns the gene BIRC3 and MALT lymphoma.