The chromosomal translocation t(14;19)(q32;12) which juxtaposes BCL3 with the IGH locus has been reported to result in an enhanced expression of BCL3 in a variety of lymphoid cancers, such as CLL and less commonly follicular lymphoma as well as marginal-zone lymphoma (Figure 6c) [226,227,228]. This evidence concerns the gene BCL3 and B-cell chronic lymphocytic leukemia.