The L265P mutation of MyD88 occurs at a high frequency in ABC DLBCL (30% of cases) and in Waldenström’s macroglobulinemia (WM; 90%) as well as less commonly in marginal-zone lymphoma (13%), gastric MALT lymphoma (9%), and CLL (3%) [40,41,42,43,44]. The gene discussed is MYD88; the disease is diffuse large B-cell lymphoma.