To date, several lymphoid malignancies, such as Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL) of the activated B cell-like (ABC) subtype, lymphomas of the mucosa-associated lymphoid tissue (MALT), primary mediastinal B-cell lymphoma (PMBL), mantle cell lymphoma (MCL), multiple myeloma, and chronic lymphocytic leukemia (CLL), have been associated with aberrant NF-κB signaling [15,16,17,18,19,20,21,22,23,24]. The gene discussed is NFKB1; the disease is mantle cell lymphoma.