More specifically, the analysis of 12 proteins (IL-2, IL-4, IL-5, IL-10, IL-13, IL-21, IL-35, IFN-β, IFN-γ, PPY, SDF-1, SEZ6L) with values that are below the level of detection (LOD, as defined by Olink) in >70% samples and low values in the others, were not included and four tumor/normal sample pairs, where internal and/or detection controls failed, were excluded. The gene discussed is IL21; the disease is neoplasm.