Here, most HPV-positive tumors separated into clusters, mainly due to differences in the expression of immune related proteins on the cell surface of tumor infiltrating immune cells, e.g., PD-1, FasL, NCR1, and KLRD1 or soluble cytokines/chemokines e.g., IL12 and CCL4 (Figure 1B). This evidence concerns the gene KLRD1 and neoplasm.