CD4 and neoplasm: A higher CD8A expression was expected, since increased numbers of CD8+, FoxP3+, and CD4+ TILs in HPV-positive vs. HPV-negative OPSCC have been noted earlier, where in particular a higher number of CD8+TILs is linked to a better clinical outcome, irrespective of the HPV status of the tumor [19,21,22].