TP53 and early-onset autosomal dominant Alzheimer disease: An increase in the neuronal “prone to die” state, promoting Alzheimer’s disease in DS, may be due in part to altered levels of anti-apoptotic proteins: Bax apoptosis-activating proteins were elevated and anti-apoptotic Bcl-2, heat shock protein 70, neuronal apoptosis inhibitory protein and p53 were decreased [67].