Others, pertinent to the DS, Alzheimer’s, and cancer relationship, include the APP gene, transcriptional factors such as ETS proto-oncogene 2 (ETS2), the angiogenesis suppressors Dscr1 and Dyrk1A and the collagen-18 gene whose fragment, endostatin, is an anti-angiogenic compound [63,64,65]. The gene discussed is APP; the disease is cancer.