The increased rate of childhood leukemia in DS seems to be an exception to the low rates of other cancers, but an interesting possibility is that the anti-angiogenesis genes on chromosome 21 would not have a suppressing role in leukemia, which is not dependent on new blood vessels; any leukemia-stimulating effects of leptin would also not be impeded by decreased angiogenesis. The gene discussed is LEP; the disease is Dravet syndrome.