For example, increased adiponectin in older DS patients might decrease angiogenesis in concert with the known anti-angiogenesis factors on chromosome 21, leading to increased Alzheimer’s disease risk but reduced adult cancer risk; anti-angiogenesis should not affect any leptin-related childhood leukemia risk, because leukemia does not require new blood vessels to grow. This evidence concerns the gene ADIPOQ and early-onset autosomal dominant Alzheimer disease.