Mutations in VCP (encoding valosin-containing protein, also known as p97 or Cdc48), cause ALS, FTD and a related syndrome known as inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD) (Watts et al., 2004; Johnson et al., 2010). The gene discussed is VCP; the disease is inclusion body myopathy with Paget disease of bone and frontotemporal dementia.