In addition, mutations in other RNA processing factors, such as FUS (encoding fused in sarcoma) (Kwiatkowski et al., 2009; Vance et al., 2009), SETX (encoding senataxin) (Chen et al., 2004), and HNRNPA/B (encoding heterogeneous nuclear ribonucleoprotein A/B, hnRNPAB) (Kim et al., 2013) also cause ALS. The gene discussed is SETX; the disease is amyotrophic lateral sclerosis.