Experiments also showed that cGMP attenuated AKI by enhancing mitochondria biogenesis and promoting mitochondria biogenesis related genes peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), NADH dehydrogenase 1 beta subcomplex subunit 8 (NDUFβ8) in renal cortex and in renal proximal tubular cells [47]. This evidence concerns the gene PPARGC1A and acute kidney injury.