High levels of VEGF induce enlarging tumor volumes and a remodeling of the vascular structures along with a reduced infiltration of microglia/macrophages of around 50%, with a minor accumulation of microglia/macrophages within the perivascular spaces; concomitantly the release of pro-angiogenic factors, such as VEGF declined, suggesting a possible regulatory feedback mechanism [56]. The gene discussed is VEGFA; the disease is neoplasm.