PATZ1 and neoplasm: It has been previously reported that PATZ1 is downregulated in thyroid cancer cell lines and tissues compared to normal thyroid cell lines and tissue, and its expression is inversely correlated with the degree of malignancy of thyroid carcinomas being lower in PDTC and ATC compared with PTC [10,11,23], then suggesting a tumor suppressor role of PATZ1 in the progression from PTC to ATC.