Importantly, at the observed time-window of age, the more aggressive solid variant of PTC was present in 3 out of 14 carcinomas (21%) in RET/PTC1;Patz1+/− mice, compared with 1 out of 12 carcinomas (8%) in RET/PTC1TG;Patz1+/+ mice. This evidence concerns the gene RET and carcinoma.