In the time-window of 10–17 months of age, thyroid carcinomas were present in 100% of RET/PTC1TG;Patz1−/−, whereas they were diagnosed in 54% and 58% of RET/PTC1TG;Patz1+/+ and RET/PTC1;Patz1+/− mice, respectively, that also show the presence of hyperplasia/goiter (Table 1). Here, RET is linked to hyperplasia.