Then, in order to validate the tumor suppressor role of PATZ1 in thyroid carcinogenesis in vivo, we crossed a mouse model of PTC, carrying the RET/PTC1 oncogene under the thyroid-specific control of the bovine thyroglobulin promoter [13] with mice knockout for the Patz1 gene [21]. The gene discussed is PATZ1; the disease is thyroid gland disorder.