RET and thyroid tumor: As shown in Figure 1a, double mutant RET/PTC1TG;Patz1−/− mice developed thyroid tumors with higher incidence (100%) and earlier onset (median age of tumor incidence of 14 months) than their RET/PTC1TG;Patz1+/+ compound mice (54% of tumors at a median age of 18 months) (p = 0.0105, Log-rank (Mantell-Cox) test; HR = 0.3831; 95% CI 0.05877–0.6138).