MUC5AC and intrahepatic cholangiocarcinoma: These results suggest that the subgroup of ICC with high integrin expression may partly resemble the large bile duct type defined by Aishima et al. [22], the bile duct type defined by Liau et al. [10], and the muc-ICC defined by Komuta et al. [9], as indicated by the non-peripheral central localization around the intrahepatic large bile ducts, periductal infiltration, and mucin production, as well as the cytoplasmic expression of EMA.