A possible explanation for the low concentrations of the non-functional t-ucMGP isoform identified with respect to the presence of calcification in a number of the reviewed studies [29,36] is that messenger-RNA expression does not increase in this high risk cardiovascular disease subtype, resulting in a relative deficiency of MGP secretion and subsequently, predisposing arteries to a high rate of calcification development [25,47]. The gene discussed is MGP; the disease is cardiovascular disorder.