Studies have been performed on the delivery of therapeutic genes by MSCs that capitalize on MSC’s self-proliferation and differentiation capacities and that have employed MSCs transduced with therapeutic genes such as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a trans-membrane protein that causes selective apoptosis in tumor cells [13,14]. The gene discussed is TNFSF10; the disease is neoplasm.