The role of the CaR in cardiac hypertrophy and heart failure was further investigated in a successive work [231], in which Calindol and Calhex 231, as agonist and inhibitor of the CaR, respectively, were subcutaneously injected in isoproterenol-treated Wistar rats to assess the role of the CaR in ER stress in vivo. Here, CASR is linked to cardiac hypertrophy.