Considering that presynaptic nucleotide receptors are involved in the vesicular release of numerous neurotransmitters, such as ACh, Glutamate, or GABA [79,80,81], and also favor amyloid processing of APP [82], the alteration of nucleotide signaling by changes of TNAP expression may contribute both to the synaptopathy and to the generation of senile plaques detected in AD. The gene discussed is APP; the disease is Alzheimer disease.