EGFR and neoplasm: As epidermal growth factor receptor (EGFR) is highly expressed on the surface of tumor cells, active targeting could be achieved through the surface modification of nanoparticles with a targeting ligand, the EGFR monoclonal antibody (cetuximab, CET), to increase the bindings of drug-loaded nanocarriers with surface receptors of cancer cells and to significantly enhance their intracellular uptake by targeted cancer cells [13,14].