Inaddition, mutant strains raised in advanced stages of the infection can use theC-X-C chemokine receptor type 4 (CXCR4) as a co-receptor to mediate viral entry.However, CXCR4 has not been defined as a preferential anti-HIV target since it isalso the transmembrane protein that guides CD4+ cells to inflammatory sites and isthus regarded as highly relevant for immune activity (McGowan and Shah, 2010). The gene discussed is CXCR4; the disease is infection.