TLR4 and periodontal disorder: IL‐6 is a proinflammatory cytokine that induces bone resorption and plays a major role in acute inflammation.28 The chemoattractants IL‐8 and MCP‐1 are of great importance for immunopathogenesis of periodontal disease.29 Furthermore, gene expression levels of TLR2 and TLR4 were measured.