TLRs pertain to a family of transmembrane proteins that are involved in recognition of invading pathogens.30 The expression of TLR2 and TLR4 is altered in periodontal disease and therefore these receptors are discussed to play an important role in disease progression.31 TLR4 activation by different bacterial LPS induces the production of inflammatory mediators in hPDLCs.22 Similarly, TLR2 activation results in cytokine production by PDLs32 and gingival fibroblasts.33 The gene discussed is TLR4; the disease is periodontal disorder.