Data of the present study show that the response of hPDLCs to TLR2 is significantly higher than that to bacterial LPS, which is in agreement with our previous reports.22, 26 Therefore, detailed examination of TLR2 induced response and its potential modulation might be important for understanding pathogenesis of periodontal disease and development of new treatment modalities. This evidence concerns the gene TLR2 and periodontal disorder.