μ Receptor coupling through Gi/Go proteins results in activation of http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=74 (GIRKs) and inhibition of voltage‐gated calcium channels (North and Williams, 1985; Seward et al.,1991), and it has been reported that the respiratory depression induced by either DAMGO, applied locally in the ventrolateral medulla, or http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1626, administered systemically, is attenuated in GIRK2 subunit knockout mice (Montandon et al.,2016). Here, KCNJ6 is linked to respiratory depression.